EFFECTS OF ACTIVATORS AND INHIBITORS OF PROTEIN-KINASE-C ON X-RAY-INDUCED MALIGNANT TRANSFORMATION INVITRO

被引：2
|
作者：
UMANS, RS
KENNEDY, AR
机构：
[1] UNIV PENN,SCH MED,DEPT RADIAT ONCOL,PHILADELPHIA,PA 19104
[2] WELLESLEY COLL,DEPT CHEM,WELLESLEY,MA 02181
来源：
EUROPEAN JOURNAL OF CANCER | 1992年 / 28A卷 / 4-5期
关键词：
D O I：
10.1016/0959-8049(92)90105-B
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We have examined the effects on X-ray induced malignant transformation in vitro of a number of activators and inhibitors of protein kinase C (PKC). Several of these substances were found to enhance or inhibit transformation, and the extent of the effects on transformation were found to be consistent with the potencies of the substances in activating or inhibiting PKC. Additionally, the observed transformation enhancement was found to be reversed by the presence of the anticarcinogenic protease inhibitors antipain or the Bowman-Birk inhibitor. These results suggest that activation of protein kinase C may be involved in the mechanism of in vitro X-ray induced malignant transformation.
引用
收藏
页码：732 / 735
页数：4
相关论文
共 50 条
  • [31] EFFECTS OF PROTEIN KINASE-C ACTIVATORS ON THE INVITRO ACTION OF THYROTROPIN IN PIGS
    GINSBERG, J
    MURRAY, PG
    JOURNAL OF ENDOCRINOLOGY, 1988, 118 (02) : 199 - 203
  • [32] THE EFFECTS OF PROTEIN-KINASE-C ACTIVATORS ON CALCIUM MOBILIZATION IN NEURONAL CELL-LINES
    OSUGI, T
    IMAIZUMI, T
    UCHIDA, S
    YOSHIDA, H
    JAPANESE JOURNAL OF PHARMACOLOGY, 1986, 40 : P45 - P45
  • [33] SYNERGISTIC EFFECTS OF A CALCIUM IONOPHORE AND ACTIVATORS OF PROTEIN-KINASE-C ON EPITHELIAL PARACELLULAR PERMEABILITY
    WINTER, MC
    PETERSON, MW
    SHASBY, DM
    AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 1991, 4 (05) : 470 - 477
  • [34] COMPARISON OF THE EFFECTS OF AURANOFIN, HEAVY-METALS AND RETINOIDS ON PROTEIN-KINASE-C INVITRO AND ON A PROTEIN-KINASE-C MEDIATED RESPONSE IN MACROPHAGES
    LISON, D
    RAGUZZI, F
    LAUWERYS, R
    PHARMACOLOGY & TOXICOLOGY, 1990, 67 (03): : 239 - 242
  • [35] STRUCTURAL INVESTIGATION OF PROTEIN-KINASE-C INHIBITORS
    BARAK, D
    SHIBATA, M
    REIN, R
    JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM, 1991, 76 : 419 - 429
  • [36] EFFECTS OF PROTEIN-KINASE-C INHIBITORS ON PROLIFERATION AND DIFFERENTIATION OF HUMAN KERATINOCYTES
    PONEC, M
    KEMPENAAR, J
    HEGEMANN, L
    CLINICAL RESEARCH, 1991, 39 (02): : A493 - A493
  • [37] EFFECTS OF PROTEIN-KINASE-C INHIBITORS ON PROLIFERATION AND DIFFERENTIATION OF HUMAN KERATINOCYTES
    PONEC, M
    KEMPENAAR, J
    HEGEMANN, L
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1991, 96 (04) : 558 - 558
  • [38] THERAPEUTIC POTENTIAL OF PROTEIN-KINASE-C INHIBITORS
    BRADSHAW, D
    HILL, CH
    NIXON, JS
    WILKINSON, SE
    AGENTS AND ACTIONS, 1993, 38 (1-2): : 135 - 147
  • [39] TANNINS AS SELECTIVE INHIBITORS OF PROTEIN-KINASE-C
    KASHIWADA, Y
    NONAKA, GI
    NISHIOKA, I
    BALLAS, LM
    JIANG, JB
    JANZEN, WP
    LEE, KH
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1992, 2 (03) : 239 - 244
  • [40] EFFECTS OF TAMOXIFEN AND PROTEIN-KINASE-C INHIBITORS ON HYPERTHERMIC CELL KILLING
    MIKKELSEN, RB
    STEDMAN, T
    SCHMIDTULLRICH, R
    LIN, PS
    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1991, 20 (05): : 1039 - 1045
12345