DISCRIMINATIVE STIMULUS PROPERTIES OF 8-OH-DPAT IN RATS ARE NOT ALTERED BY PRETREATMENT WITH PARA-CHLOROPHENYLALANINE

被引：13
|
作者：
KALKMAN, HO
机构：
[1] Preclinical Research Sandoz AG, Postfach, Basel
来源：
PSYCHOPHARMACOLOGY | 1990年 / 101卷 / 01期
关键词：
5-HT[!sub]1A[!/sub] autoreceptor; 8-OH-DPAT; Drug discrimination test; pCPA; Rat;
D O I：
10.1007/BF02253715
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The role of 5-HT1A autoreceptors in the discriminative stimulus properties of 8-OH-DPAT (0.1 mg/kg, SC) in rats, was investigated. Drug lever appropriate responding to 8-OH-DPAT (0.1 mg/kg, SC) and ipsapirone (3 mg/kg, SC) was measured before and after treatment with para-chlorophenylalanine (pCPA) at a dose (150 mg/kg IP, -3 and -2 days) which causes severe depletion of brain 5-HT stores. The recognition of the drug stimulus was not significantly altered by pCPA. These results indicate that activation of 5-HT1A autoreceptors is of minimal importance to the 8-OH-DPAT cue. © 1990 Springer-Verlag.
引用
收藏
页码：39 / 42
页数：4
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