Composite Follicular Lymphoma and CD5-Positive Nodal Marginal Zone Lymphoma

被引：6
|
作者：
Miyaoka, Masashi [1 ]
Kikuchi, Tomoki [1 ]
Carreras, Joaquim [1 ]
Kikuti, Yukie Yara [1 ]
Omachi, Ken [2 ]
Kojima, Minoru [2 ]
Ando, Kiyoshi [2 ]
Nakamura, Naoya [1 ]
机构：
[1] Tokai Univ, Sch Med, Dept Pathol, 143 Shimokasuya, Isehara, Kanagawa 2591193, Japan
[2] Tokai Univ, Sch Med, Dept Internal Med, Div Hematol Oncol, Isehara, Kanagawa, Japan
来源：
JOURNAL OF CLINICAL AND EXPERIMENTAL HEMATOPATHOLOGY | 2016年 / 56卷 / 01期
关键词：
composite lymphoma; follicular lymphoma; CD5-positive nodal marginal zone lymphoma;
D O I：
10.3960/jslrt.56.55
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Composite CD10-positive low-grade B-cell and CD5-positive low-grade B-cell lymphoma is extremely rare. We report a case of a composite follicular lymphoma (FL) and CD5-positive nodal marginal zone lymphoma (NMZL) in a resected inguinal lymph node of a 72-year-old Japanese male. Histologically, multiple follicles had reactive-germinal centers with tingible body macrophages, a thin mantle zone and a wide marginal zone. The wide marginal zone consisted of medium-sized cells having slightly indented nuclei and clear cytoplasm, indicating monocytoid cells with CD5-positive B-cells. Several follicles had germinal centers filled with many centrocytes, with CD10-positive B-cells. Polymerase chain reaction/sequence analysis of the immunoglobulin heavy chain gene obtained from microdissected regions of CD5-positive NMZL and FL showed different sequences within the CDR3 region. To our knowledge, this is the first report of FL and CD5-positive NMZL.
引用
收藏
页码：55 / 58
页数：4
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