ENDOGENOUS OPIOID MODULATION OF HYPERCAPNIC-STIMULATED RESPIRATION IN THE RAT

被引:13
|
作者
EAGER, KR
ROBINSON, BJ
GALLETLY, DC
MILLER, JH
机构
[1] VICTORIA UNIV WELLINGTON,SCH BIOL SCI,WELLINGTON,NEW ZEALAND
[2] WELLINGTON SCH MED,DEPT SURG,ANAESTHESIA SECT,WELLINGTON,NEW ZEALAND
来源
RESPIRATION PHYSIOLOGY | 1994年 / 96卷 / 01期
关键词
CONTROL OF BREATHING; CO2; RESPONSE; MAMMALS; RAT; MEDIATORS; OPIOIDS; VENTILATORY CO2 RESPONSE; AGONIST; ANTAGONIST; PHARMACOLOGICAL AGENTS; DEMORPHIN; NALOXONE;
D O I
10.1016/0034-5687(94)90102-3
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
The role of endogenous opioids in respiratory control in the pentobarbital anaesthetised rat was investigated using a rebreathing technique to generate a progressively increasing hypercapnic stimulus to the respiratory centers following administration of an opioid antagonist or agonist. Respiratory output was measured by intraesophageal pressure (IEP) changes, and a ventilatory equivalent (VEq) was calculated by multiplying IEP by respiratory rate (mmHg.min-1). A non-selective opioid antagonist, naloxone (0.4 mg/kg i.v.), significantly enhanced the slope of the CO2 response curve for VEq (20 +/- 3 mmHg.min-1.%CO2(-1)) compared with the control (14 +/- 2 mmHg.min-1.%CO2(-1)) (P < 0.05; n = 14). A similar enhancement of the hypercapnic response by naloxone was found in rats anaesthetised with urethane (n = 5). The mu receptor agonist dermorphin (1 mg/kg i.v.) significantly depressed the slope of the CO2 response curve for IEP (-0.01 +/- 0.03) compared with the control (0.10 +/- 0.03) in pentobarbital anaesthetised rats (P < 0.05; n = 5) but had no significant effect on respiratory rate. These results suggest a role of endogenous opioids in the modulation of respiration during hypercapnia.
引用
收藏
页码:13 / 24
页数:12
相关论文
共 50 条