MEMBRANE-ASSOCIATED PHOSPHOLIPASE-A2 DETECTED BY A RADIOIMMUNOASSAY IS A SENSITIVE MARKER OF INFLAMMATION IN RHEUMATOID-ARTHRITIS

被引：0
|
作者：
SAKAMOTO, K
ARAKAWA, H
YAMASHITA, SI
MIZUTA, H
TAKAKI, K
OGAWA, M
机构：
[1] KUMAMOTO UNIV,SCH MED,DEPT SURG 2,KUMAMOTO 860,JAPAN
[2] KUMAMOTO UNIV,SCH MED,DEPT ORTHOPED,KUMAMOTO 860,JAPAN
来源：
RESEARCH COMMUNICATIONS IN CHEMICAL PATHOLOGY AND PHARMACOLOGY | 1992年 / 76卷 / 03期
关键词：
D O I：
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中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
To investigate the clinical significance of membrane-associated phospholipase A2 (M-PLA2) measured by a radioimmunoassay(RIA) in rheumatoid arthritis, we examined serum M-PLA2 concentrations in 16 patients with rheumatoid arthritis. All showed elevated levels of serum M-PLA2 On the other hand, serum concentrations of C-reactive protein (CRP) and IL-6 were increased in 13 (81.3 %) and 14 (87.5 %) of 16 patients, respectively. The serum concentrations of M-PLA2 were significantly correlated with those of CRP These results indicate that M-PLA2 is an acute phase reactant and a sensitive and useful marker of inflammation in rheumatoid arthritis.
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页码：279 / 285
页数：7
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