THE EFFECT OF CHRONIC FATTY-ACID TREATMENT ON LIPOLYSIS IN 3T3-L1 ADIPOCYTES

被引：14
|
作者：
FONG, JC
机构：
[1] Institute of Biochemistry National Yang-Ming Medical College, Taipei
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 171卷 / 01期
关键词：
D O I：
10.1016/0006-291X(90)91354-U
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Various saturated and unsaturated fatty acids were included in the culture medium to test their effects on lipolysis in 3T3-L1 adipocytes. Following prolonged incubation, only oleate was found to exert enhancing effect on basal and isoproterenol-stimulated lipolysis. The effect of oleate was concentration-dependent and was accompanied with increased intracellular cAMP content. Furthermore, the lipolytic response induced by isobutylmethylxanthine, forskolin or dibutyryl cAMP was also increased in adipocytes treated with oleate. Thus, it appears that in addition to an increased cAMP accumulation, a step distal to cAMP production in the cells may be involved in inducing enhanced lipolysis in 3T3-L1 adipocytes by prolonged exposure to oleate. © 1990.
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页码：46 / 52
页数：7
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