Simpler and Faster Spectrophotometric Determination of Diclofenac Sodium in Tablets, Serum and Urine Samples

被引：0
|
作者：
Khaskheli, Abdul Rauf [1 ]
Sirajuddin [1 ]
Abro, Kamran [1 ,2 ]
Sherazi, S. T. H. [1 ]
Afridi, H. I. [1 ]
Mahesar, S. A. [1 ]
Saeed, Munawar [1 ]
机构：
[1] Univ Sindh, Natl Ctr Excellence Analyt Chem, Jamshoro 76080, Pakistan
[2] Pakistan Council Sci & Ind Res, Karachi 75280, Pakistan
来源：
PAKISTAN JOURNAL OF ANALYTICAL & ENVIRONMENTAL CHEMISTRY | 2009年 / 10卷 / 1-2期
关键词：
Diclofenac sodium; UV-Visible spectrophotometer; tablets; serum; urine;
D O I：
暂无
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
This work describes a simple, sensitive, rapid and economical analytical procedure for direct spectrophotometric evaluation of diclofenac sodium (DS) using aqueous medium without using a chemical reagent. Parameters like time, temperature, acidic and basic conditions and interference by analgesic drugs were studied for a 5 mu g ml(-1) solution of DS at 276 nm. Under optimized parameters, a linear working range of 0.1-30 mu g ml(-1) with regression coefficient of 0.9998 and lower detection limit of 0.01 mu g ml(-1) was obtained. The method was applied for DS contents in tablets, serum and urine samples.
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页码：53 / 58
页数：6
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