Organocatalytic Asymmetric Domino [3+2]-Cycloaddition-Acyl Transfer Reaction between Azomethine Ylides and a-Nitro-a,β-Unsaturated Ketones

被引：1

作者：

Sahoo, Subas Chandra ^{[1
]}

Parida, Chandrakanta ^{[1
]}

Pan, Subhas Chandra ^{[1
]}

机构：

[1] Indian Inst Technol Guwahati, Dept Chem, North Guwahati 781039, Assam, India

来源：

CHEMISTRY-AN ASIAN JOURNAL | 2023年 / 18卷 / 19期

关键词：

Organocatalytic; Asymmetric; Acyl transfer reagent; Pyrrolidine; Squaramide;

D O I：

10.1002/asia.202300563

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Herein we have developed an organocatalytic asymmetric domino [3+ 2]-cycloaddition-acyl transfer reaction between in situ generated azomethine ylides and alpha-nitro-alpha, beta-unsaturated ketones. The desired penta-substituted pyrrolidine products were obtained in high yields and in moderate to good enantio- and diastereoselectivities. Also, an isomerization reaction in silica gel was performed for the formation of another diastereomer in high yields with retention of enantioselectivities.

引用

页数：6

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