LOCALIZATION OF DOPAMINE D2 RECEPTOR MESSENGER-RNA IN GLOMUS CELLS OF THE RABBIT CAROTID-BODY BY IN-SITU HYBRIDIZATION

被引：13
|
作者：
VERNA, A
SCHAMEL, A
LEMOINE, C
BLOCH, B
机构：
[1] CNRS, URA 339, F-33405 TALENCE, FRANCE
[2] UNIV BORDEAUX 2, HISTOL EMBRYOL LAB, BORDEAUX, FRANCE
[3] CNRS, URA 1200, F-33076 BORDEAUX, FRANCE
来源：
JOURNAL OF NEUROCYTOLOGY | 1995年 / 24卷 / 04期
关键词：
D O I：
10.1007/BF01186539
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The localization of mRNA coding for the dopamine D2 receptor was studied in the rabbit carotid body using in situ hybridization with synthetic S-35-labelled oligodeoxynucleotides. Using autoradiography on cryostat or semi-thin sections, labelling was observed over the cytoplasm of glomus cells, but not over sustentacular cells. A quantitative study showed that labelling intensity (silver grain density) was increased by haloperidol treatment. These results suggest that glomus cells express the dopamine D2 receptor gene and that this expression is regulated.
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页码：265 / 270
页数：6
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