In a study by questionnaire and anthropometric measurements of the effect of sickle cell disease on the health growth and education of 102 Nigerian children aged between 9 months and 17 years, the first symptoms of the disease had occurred by the age 1 1/2 years in 58.8% of them. Strenuous exercise and exposure to cold water and weather commonly precipitated illness episodes which occurred in 81.4% of the children at least bi-annually. 94.1% of the children have been hospitalised and 76.5% transfused with blood at least once each before. Of the 67 children in school only 32.8% were in their correct classes and 53.7% have lost years. The mean class examination performance score computed for 55 of those in school was 67.8% +/- 21.5 The heights fall around and the weights below the third percentile of standard growth curves for Nigerian elite children. The disease affects the parameters examined adversely and should be controlled more effectively.