ATTENUATION OF HIPPOCAMPAL KAINIC ACID-INDUCED SEIZURES BY SUBSTANCE-P TREATMENT

被引：7
|
作者：
KLAPDOR, K
SPRICK, U
HUSTON, JP
机构：
[1] UNIV DUSSELDORF,INST PHYSIOL PSYCHOL 1,D-40225 DUSSELDORF,GERMANY
[2] UNIV DUSSELDORF,C&O VOGT INST BRAIN RES,D-40225 DUSSELDORF,GERMANY
来源：
PEPTIDES | 1994年 / 15卷 / 03期
关键词：
SUBSTANCE P; KAINIC ACID; SEIZURES; EPILEPSY;
D O I：
10.1016/0196-9781(94)90199-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Adult male Wistar rats (n = 21) received bilateral kainic acid lesions of their hippocampi. Over a period of 9 weeks the animals received daily IP injections of either 5 mu g/kg or 50 mu g/kg substance P (SP) or vehicle. Seizures provoked by the lesions were suppressed by the daily administration of the neuropeptide SP in a dose of 50 mu g/kg for the whole period of observation. The neurokinin significantly (p < 0.01) reduced the number of seizures compared to the vehicle-treated animals.
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页码：425 / 427
页数：3
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