The bone mineral content in a standardized site was measured in 25 edentulous mandibles with dual-photon absorptiometry. The results of the bone mineral content examinations demonstrated a significant difference between the sexes. With advancing age of the subjects, the values measured in the men's mandibles tended to increase slightly, whereas those in the women's mandibles tended to decrease. As a functional adaptation to preserve the stability of the male atrophic mandible, the amount of inner cortical bone is increased. Explanations for this observation are discussed. That the mandibles of men and women change differently with increasing age should be considered in routine examinations, because osteoporosis may be regarded as a cofactor of residual ridge resorption in women.