CYTOGENETIC STUDIES IN 3 XENOGRAFTED NASOPHARYNGEAL CARCINOMAS

被引：21
|
作者：
BERNHEIM, A
ROUSSELET, G
MASSAAD, L
BUSSON, P
TURSZ, T
机构：
[1] INST GUSTAVE ROUSSY,CYTOGENET & GENET ONCOL LAB,CNRS,URA 1156,F-94805 VILLEJUIF,FRANCE
[2] INST GUSTAVE ROUSSY,IMMUNOL TUMEURS LAB,CNRS,UA 1156,F-94805 VILLEJUIF,FRANCE
来源：
CANCER GENETICS AND CYTOGENETICS | 1993年 / 66卷 / 01期
关键词：
D O I：
10.1016/0165-4608(93)90141-8
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Cytogenetics results of three xenografted nasopharyngeal carcinomas (NPC) are reported. One (C15) was almost diploid and had only an isochromosome 1q, trisomy 2, and loss of chromosome X. The two other tumors, C17 and C19, were hypodiploid and had complex karyotypes with some variations. Nonrandom structural abnormalities of chromosomes 1, 3, 8, and 17 were observed. A correlation between a del(17)(p11-12) observed in C17 and loss of both alleles of p53 recently shown in this tumor is emphasized.
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页码：11 / 15
页数：5
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