Ideal Cure for Hepatitis B Infection: The Target is in Sight

被引：3
|
作者：
Anikhindi, Shrihari A. [1 ,2 ]
Kumar, Ashish [1 ,2 ]
Sharma, Praveen [1 ,2 ]
Singla, Vikas [1 ,2 ]
Bansal, Naresh [1 ,2 ]
Arora, Anil [1 ,2 ]
机构：
[1] Sir Ganga Ram Hosp, Dept Gastroenterol, New Delhi, India
[2] Sir Ganga Ram Hosp, Dept Pathol, New Delhi, India
来源：
JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY | 2018年 / 8卷 / 02期
关键词：
cccDNA; HBV; antivirals;
D O I：
10.1016/j.jceh.2017.10.002
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Hepatitis B virus (HBV) is one of the most common causes of liver cirrhosis and hepatocellular carcinoma. Despite recent strides in pharmacotherapy, complete cure of HBV infection still remains an enigma. The biggest obstacle in HBV therapy is clearance of covalently closed circular deoxyribonucleic acid (cccDNA). We discuss about the role of cccDNA in HBV life cycle, efficacy and shortcomings of currently available antivirals as well as promising novel targets to achieve ideal HBV cure.
引用
收藏
页码：188 / 194
页数：7
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