Ideal Cure for Hepatitis B Infection: The Target is in Sight

被引：3
|
作者：
Anikhindi, Shrihari A. [1 ,2 ]
Kumar, Ashish [1 ,2 ]
Sharma, Praveen [1 ,2 ]
Singla, Vikas [1 ,2 ]
Bansal, Naresh [1 ,2 ]
Arora, Anil [1 ,2 ]
机构：
[1] Sir Ganga Ram Hosp, Dept Gastroenterol, New Delhi, India
[2] Sir Ganga Ram Hosp, Dept Pathol, New Delhi, India
来源：
JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY | 2018年 / 8卷 / 02期
关键词：
cccDNA; HBV; antivirals;
D O I：
10.1016/j.jceh.2017.10.002
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Hepatitis B virus (HBV) is one of the most common causes of liver cirrhosis and hepatocellular carcinoma. Despite recent strides in pharmacotherapy, complete cure of HBV infection still remains an enigma. The biggest obstacle in HBV therapy is clearance of covalently closed circular deoxyribonucleic acid (cccDNA). We discuss about the role of cccDNA in HBV life cycle, efficacy and shortcomings of currently available antivirals as well as promising novel targets to achieve ideal HBV cure.
引用
收藏
页码：188 / 194
页数：7
相关论文
共 50 条
  • [1] HBx protein as a therapeutic target for functional cure of hepatitis B virus infection
    Kumar, Vijay
    VIROLOGY, 2025, 604
  • [2] Is cure of HIV infection in sight?
    Shete, Ashwini
    Paranjape, R. S.
    INDIAN JOURNAL OF MEDICAL RESEARCH, 2013, 138 : 824 - 828
  • [3] Stopping oral antiviral treatment to cure chronic hepatitis B, is it in sight?
    Rong Fan
    Jinlin Hou
    Hepatology International, 2020, 14 : 302 - 304
  • [4] Stopping oral antiviral treatment to cure chronic hepatitis B, is it in sight?
    Fan, Rong
    Hou, Jinlin
    HEPATOLOGY INTERNATIONAL, 2020, 14 (03) : 302 - 304
  • [5] Eliminating cccDNA to cure hepatitis B virus infection
    Zoulim, Fabien
    Testoni, Barbara
    JOURNAL OF HEPATOLOGY, 2023, 78 (04) : 677 - 680
  • [6] Letter: the perilous road to a functional cure for hepatitis B infection
    Yilmaz, Yusuf
    ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2020, 51 (05) : 577 - 577
  • [7] Chronic Hepatitis B Infection: New Approaches towards Cure
    Ogunnaike, Mojisola
    Das, Srijanee
    Raut, Samiksha S.
    Sultana, Ashrafi
    Nayan, Mohammad Ullah
    Ganesan, Murali
    Edagwa, Benson J.
    Osna, Natalia A.
    Poluektova, Larisa Y.
    BIOMOLECULES, 2023, 13 (08)
  • [8] The roadmap towards cure of chronic hepatitis B virus infection
    Gane, Edward
    JOURNAL OF THE ROYAL SOCIETY OF NEW ZEALAND, 2022, 52 (02) : 129 - 148
  • [9] Therapeutic strategies for hepatitis B virus infection: towards a cure
    Fanning, Gregory C.
    Zoulim, Fabien
    Hou, Jinlin
    Bertoletti, Antonio
    NATURE REVIEWS DRUG DISCOVERY, 2019, 18 (11) : 827 - 844
  • [10] Therapeutic strategies for hepatitis B virus infection: towards a cure
    Gregory C. Fanning
    Fabien Zoulim
    Jinlin Hou
    Antonio Bertoletti
    Nature Reviews Drug Discovery, 2019, 18 : 827 - 844
12345