ATOPIC ECZEMA;
SKIN MICROORGANISMS;
STAPHYLOCOCCUS-AUREUS;
PITYROSPORUM-OVALE;
SPECIFIC IGE ANTIBODIES;
D O I:
10.1111/j.1398-9995.1992.tb02051.x
中图分类号:
R392 [医学免疫学];
学科分类号:
100102 ;
摘要:
The pathophysiology of atopic eczema (AE) is still poorly understood. One possible concept favors IgE-mediated reactivity towards allergens that enter the skin from the outside or through the blood. Microorganisms of the cutaneous flora also might represent a stimulus for allergic skin reactions. Abnormal bacterial skin colonization is a characteristic feature of AE. Staphylococcus aureus (S. aureus) is the most common pathogen. Binding to host cells involves special receptors, such as fibronectin or laminin. Specific IgE antibodies to S. aureus can be detected in the blood. Whereas the clinical relevance of anti-staphylococcal antibodies is still controversial, specific IgE antibodies to Pityrosporum species as well as positive type I prick test reactions to these yeasts seem to correlate with the intensity of eczematous lesions in the head and neck regions of patients with AE. Both antimicrobial and antifungal treatment has been shown helpful in some cases of AE.
机构:
Kings Coll London, Dept Paediat Allergy, Div Asthma Allergy & Lung Biol, London, England
Guys & St Thomas NHS Fdn Trust, St Thomas Hosp, Childrens Allergies Dept, Westminster Bridge Rd, Lambeth SE1 7EH, EnglandKings Coll London, Dept Paediat Allergy, Div Asthma Allergy & Lung Biol, London, England
Marrs, T.
Flohr, C.
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机构:
Kings Coll London, Div Genet & Mol Med, St Johns Inst Dermatol, Unit Populat Based Dermatol Res, London, England
Guys & St Thomas Hosp NHS Fdn Trust, London, EnglandKings Coll London, Dept Paediat Allergy, Div Asthma Allergy & Lung Biol, London, England
机构:
Univ Cape Town, Div Dermatol, Cape Town, South Africa
New Groote Schuur Hosp, Cape Town, South AfricaUniv Cape Town, Div Dermatol, Cape Town, South Africa