Microbiota in Healthy Skin and in Atopic Eczema

被引:48
|
作者
Baviera, Giuseppe [1 ]
Leoni, Maria Chiara [2 ]
Capra, Lucetta [3 ]
Cipriani, Francesca [4 ]
Longo, Giorgio [5 ]
Maiello, Nunzia [6 ]
Ricci, Giampaolo [4 ]
Galli, Elena [7 ]
机构
[1] Natl Hlth Syst Pediatrician ASL RMC D6, Rome, Italy
[2] Univ Pavia, Dept Clin Surg Diagnost & Pediat Sci, Pediat Unit, I-27100 Pavia, Italy
[3] Univ Hosp S Anna, Dept Reprod & Pediat, Ferrara, Italy
[4] Univ Bologna, Dept Med & Surg Sci, Pediat Unit, Bologna, Italy
[5] Univ Trieste, Trieste, Italy
[6] Univ Naples 2, Dept Woman Child & Gen & Specialized Sur, Naples, Italy
[7] San Pietro Hosp Fatebenefratelli, Res Ctr, Pediat Allergy Unit, Rome, Italy
关键词
NASAL CARRIAGE; STAPHYLOCOCCUS-EPIDERMIDIS; COMMENSAL BACTERIA; BODY HABITATS; DIVERSITY; MECHANISMS; MECONIUM; IMMUNITY; DISEASE; BARRIER;
D O I
10.1155/2014/436921
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The Italian interest group (IG) on atopic eczema and urticaria is member of the Italian Society of Allergology and Immunology. The aim of our IG is to provide a platform for scientists, clinicians, and experts. In this review we discuss the role of skin microbiota not only in healthy skin but also in skin suffering from atopic dermatitis (AD). A Medline and Embase search was conducted for studies evaluating the role of skin microbiota. We examine microbiota composition and its development within days after birth; we describe the role of specific groups of microorganisms that colonize distinct anatomical niches and the biology and clinical relevance of antimicrobial peptides expressed in the skin. Specific AD disease states are characterized by concurrent and anticorrelated shifts in microbial diversity and proportion of Staphylococcus. These organisms may protect the host, defining them not as simple symbiotic microbes but rather as mutualistic microbes. These findings reveal links between microbial communities and inflammatory diseases such as AD and provide novel insights into global shifts of bacteria relevant to disease progression and treatment. This review also highlights recent observations on the importance of innate immune systems and the relationship with normal skin microflora for the maintenance of healthy skin.
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页数:6
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