AGONISTIC-ANTAGONISTIC ACTIONS OF CLOMIPHENE CITRATE ON PGF2-ALPHA FLUCTUATIONS IN OVARIECTOMIZED RAT UTERUS

被引：0
|
作者：
KOGO, H
HIKIKOSHI, A
机构：
[1] Department of Pharmacology, Tokyo College of Pharmacy, Tokyo
来源：
JAPANESE JOURNAL OF PHARMACOLOGY | 1992年 / 58卷 / 02期
关键词：
D O I：
10.1254/jjp.58.197
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Effects of clomiphene and/or estrogen on uterine prostaglandin (PG) F2-alpha fluctuations in ovariectomized rats were examined. Uterine PGF2-alpha fluctuations were measured at the indicated times after injection of clomiphene and/or estradiol. Antiestrogenic effects of clomiphene on urine weight and PGF2-alpha levels were observed at 6 hr, and its effect on uterine 13,14-dihydro-15-keto-PGF2-alpha forming capacity was observed at 24 hr. At 48 and 72 hr, additive effects were recognized in all parameters. These results indicate that clomiphene possesses agonistic-antagonistic actions on the PGF2-alpha fluctuations in the uterus.
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页码：197 / 200
页数：4
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