AGONISTIC-ANTAGONISTIC ACTIONS OF CLOMIPHENE CITRATE ON PGF2-ALPHA FLUCTUATIONS IN OVARIECTOMIZED RAT UTERUS

被引：0
|
作者：
KOGO, H
HIKIKOSHI, A
机构：
[1] Department of Pharmacology, Tokyo College of Pharmacy, Tokyo
来源：
JAPANESE JOURNAL OF PHARMACOLOGY | 1992年 / 58卷 / 02期
关键词：
D O I：
10.1254/jjp.58.197
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Effects of clomiphene and/or estrogen on uterine prostaglandin (PG) F2-alpha fluctuations in ovariectomized rats were examined. Uterine PGF2-alpha fluctuations were measured at the indicated times after injection of clomiphene and/or estradiol. Antiestrogenic effects of clomiphene on urine weight and PGF2-alpha levels were observed at 6 hr, and its effect on uterine 13,14-dihydro-15-keto-PGF2-alpha forming capacity was observed at 24 hr. At 48 and 72 hr, additive effects were recognized in all parameters. These results indicate that clomiphene possesses agonistic-antagonistic actions on the PGF2-alpha fluctuations in the uterus.
引用
收藏
页码：197 / 200
页数：4
相关论文
共 50 条
  • [1] EFFECT OF ANTI-ESTROGEN ON THE VARIATION OF PGF2-ALPHA IN RAT UTERUS
    KOGO, H
    INAZU, N
    HIKIKOSHI, A
    YAMADA, K
    AIZAWA, Y
    FOLIA PHARMACOLOGICA JAPONICA, 1983, 82 (06) : P166 - P167
  • [2] INFLUENCE OF HORMONAL TREATMENTS ON SENSITIVITY OF ISOLATED UTERUS TO PGF2-ALPHA IN RAT
    MITOLOCHIEPPA, D
    ALICINO, L
    LOGRANO, M
    PHARMACOLOGICAL RESEARCH COMMUNICATIONS, 1978, 10 (03): : 205 - 210
  • [3] BLOOD LH AFTER PGF2-ALPHA IN DIESTROUS AND OVARIECTOMIZED CATTLE
    HAFS, HD
    LOUIS, TM
    STELLFLUG, JN
    CONVEY, EM
    BRITT, JH
    PROSTAGLANDINS, 1975, 10 (06): : 1001 - 1009
  • [4] DIFFERENTIAL INDUCTION OF C-JUN EXPRESSION BY PGF2-ALPHA IN RAT OVARY, UTERUS AND ADRENAL
    KHAN, I
    HOSSAIN, A
    WHITMAN, GF
    SARKAR, NH
    MCDONOUGH, PG
    PROSTAGLANDINS, 1993, 46 (02): : 139 - 144
  • [5] INFLUENCE OF ASPIRIN ON CONTRACTILE RESPONSES INDUCED PGF2-ALPHA IN RABBIT UTERUS
    KUDO, T
    TERAKI, Y
    NAKAYA, S
    FOLIA PHARMACOLOGICA JAPONICA, 1980, 76 (02) : P54 - P54
  • [6] IMMUNOHISTOCHEMICAL LOCALIZATION OF PGF2-ALPHA RECEPTOR IN THE RAT OVARY
    ORLICKY, DJ
    FISHER, L
    DUNSCOMB, N
    MILLER, GJ
    PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, 1992, 46 (03): : 223 - 229
  • [7] IMMUNOHISTOCHEMICAL LOCALIZATION OF PGF2-ALPHA RECEPTOR IN THE RAT OVIDUCT
    ORLICKY, DJ
    WILLIAMSSKIPP, C
    PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, 1993, 48 (02): : 185 - 192
  • [8] QUANTITATIVE RELATIONSHIP OF PGF2-ALPHA AND PGE2 RELEASE TO SPONTANEOUS CONTRACTILE ACTIVITY OF PREGNANT RAT UTERUS INVITRO
    DUBIN, NH
    GHODGAONKAR, RB
    BLAKE, DA
    KING, TM
    FEDERATION PROCEEDINGS, 1976, 35 (03) : 457 - 457
  • [9] PGF2-ALPHA RECEPTORS IN RAT MYOMETRIUM DURING PREGNANCY AND PARTURITION
    LINTNER, F
    HERTELENDY, F
    ZSOLNAI, B
    EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 1982, 12 (02) : 23 - 23
  • [10] THE EFFECT OF PGF2-ALPHA ON HUMAN AND RAT ORAL-MUCOSA
    TERNER, K
    JAVOR, T
    INTERNATIONAL JOURNAL OF TISSUE REACTIONS-EXPERIMENTAL AND CLINICAL ASPECTS, 1983, 5 (03): : 279 - 284
12345