PINEAL HYPERACTIVITY IN SPONTANEOUSLY HYPERTENSIVE RATS - MUSCARINIC REGULATION OF INDOLE METABOLISM

被引：8
|
作者：
FINOCCHIARO, LME [1 ]
SCHEUCHER, A [1 ]
ALVAREZ, AL [1 ]
FINKIELMAN, S [1 ]
NAHMOD, VE [1 ]
PIROLA, CJ [1 ]
机构：
[1] UNIV BUENOS AIRES,INST INVEST MED,SUSTANCIAS VASOACT LAB,DONATO ALVAREZ 3150,RA-1427 BUENOS AIRES,ARGENTINA
来源：
CLINICAL SCIENCE | 1990年 / 79卷 / 05期
关键词：
5-hydroxytryptamine; melatonin; muscarinic activity; pineal gland; spontaneously hypertensive rats;
D O I：
10.1042/cs0790437
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
1. Choline acetyltransferase activity and [3H]quinuclidinyl benzylate-binding sites were detected in the pineal gland of normotensive Wistar-Kyoto rats and of spontaneously hypertensive rats. 2. In vitro, muscarinic activation by pilocarpine increased the pineal metabolic production of hydroxyindole derivatives up to 5-hydroxytryptamine and produced a less marked stimulation of melatonin biosynthesis. 3. Electrical field stimulation of pineal gland slices caused similar metabolic effects. 4. Muscarinic blockade with atropine inhibited the effects on hydroxyindole metabolism. 5. [3H]Quinuclidinyl benzylate-binding sites, indicative of muscarinic receptors, were more numerous, and basal 5-hydroxytryptamine and melatonin levels were higher, in the pineal gland of spontaneously hypertensive rats compared with Wistar-Kyoto rats. 6. The atropine-sensitive metabolic effects of pilocarpine and electrical field stimulation on the pineal gland were increased in spontaneously hypertensive rats compared with Wistar-Kyoto rats.
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页码：437 / 442
页数：6
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