EFFECT OF PROPIONIC-ACID ON POLY (BETA-HYDROXYBUTYRIC-CO-BETA-HYDROXYVALERIC) ACID PRODUCTION BY ALCALIGENES-EUTROPHUS

被引：28
|
作者：
KIM, JH
KIM, BG
CHOI, CY
机构：
[1] Department of Chemical Technology College of Engineering, Seoul National University, Seoul
来源：
BIOTECHNOLOGY LETTERS | 1992年 / 14卷 / 10期
关键词：
D O I：
10.1007/BF01020626
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The effect of propionic acid on poly(beta-hydroxybutyric-co-beta-hydroxyvaleric)acid P(HB-co-HV) copolymer production by Alcaligenes eutrophus ATCC 17699 supplied with fructose and propionic acid under nitrogen limited conditions was studied. The growth of A. eutrophus was almost completely inhibited when the concentration of propionic acid exceeds 1.5 g/L. Specific production rate of HV unit was highest when propionic acid concentration was 0.5 g/L. In batch culture, pH change occurs in proportion to the consumption of propionic acid. Optimal concentration of propionic acid was maintained during the production phase by using a pH-stat feeding method and a total polymer content higher than 70 % and the relative HV content upto 50 % could be achieved.
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页码：903 / 906
页数：4
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