A MODEL OF THE MECHANISMS OF LONG-TERM POTENTIATION IN THE HIPPOCAMPUS

被引：11
|
作者：
KITAJIMA, T [1 ]
HARA, K [1 ]
机构：
[1] YAMAGATA UNIV,FAC ENGN,YONEZAWA,YAMAGATA 992,JAPAN
来源：
BIOLOGICAL CYBERNETICS | 1990年 / 64卷 / 01期
关键词：
D O I：
10.1007/BF00203628
中图分类号：
TP3 [计算技术、计算机技术];
学科分类号：
0812 ;
摘要：
Long-Term Potentiation (LTP) in the hippocampus has been considered to be a phenomenon closely related to learning and memory in the brain. In this paper, an integrated model of LTP is constructed based on hypotheses about both the mechanism of LTP induction and that of LTP maintenance, that is, the NMDA-receptor channel, protein phosphorylation and protein turnover. The validity of the model is discussed based on the results of computer simulations. © 1990 Springer-Verlag.
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收藏
页码：33 / 39
页数：7
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