Treatment of chronic inflammatory intestinal diseases in children and adolescents. Therapy concepts including biologics

被引：0
|
作者：
Radke, M. [1 ]
机构：
[1] Klinikum Ernst Von Bergmann, Klin Kinder & Jugendmed, Charlottenstr 72, D-14467 Potsdam, Germany
来源：
GASTROENTEROLOGE | 2011年 / 6卷 / 06期
关键词：
Biological factors; Crohn disease; Colitis; ulcerative; TNF-alpha blockers; Remission;
D O I：
10.1007/s11377-010-0513-x
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
The treatment of children and adolescents with chronic inflammatory intestinal diseases is still problematic because of a narrow scientific basis for therapeutic decision-making. Data from studies involving adults must be evaluated with caution. Biologics, such as TNF-alpha blockers have been approved for the induction and maintenance of remission in moderate-to-severe pediatric Crohn's disease that is unresponsive to conventional therapy. Data from studies on children show a steroid-saving and growth optimizing effect. Regularly scheduled maintenance therapy is recommended. Inflixmab is also a therapeutic alternative in children with severe ulcerative colitis. Adalimumab may be used in cases of side-effects or loss of response.
引用
收藏
页码：486 / 495
页数：10
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