REDUCED RESPONSIVENESS OF IMMATURE B-CELLS TO THE B-CELL MITOGEN, LIPOPROTEIN

被引：0

作者：

PHILLIPS, RA ^{[1
]}

MELCHERS, F ^{[1
]}

机构：

[1] BASEL INST IMMUNOL, CH-4005 BASEL 5, SWITZERLAND

来源：

JOURNAL OF IMMUNOLOGY | 1979年 / 122卷 / 04期

关键词：

D O I：

暂无

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

When pre-B [bone marrow-derived] cells are isolated from [mouse] bone marrow and incubated in vitro for several days, they spontaneously differentiate into LPS[lipopolysaccharide]-reactive B cells. These newly produced B cells do not respond to another B cell mitogen, lipoprotein (Lp). The lack of Lp reactivity of newly produced B cells represents a qualitative difference between these cells and B cells in peripheral tissues that respond equally well to LPS and Lp. Responsiveness to different mitogen provides unique markers to identify B cells at early stages of development.

引用

页码：1473 / 1475

页数：3

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