Hearing status in 75 adult subjects with sickle cell disease was examined. Thirty-one (or 41%) of the subjects failed the hearing screening. When examined by hemoglobin type, it was found that persons with sickle cell C disease had the greatest incidence of hearing loss, although all subject groups exhibited greater prevalence rates than the general population. The results suggest that routine audiologic assessment be incorporated into the regular medical examination for adults with sickle cell disease (Ear Hear 12 5:349-351).