STUDIES ON SOME 10-[2-(N,N-DISUBSTITUTED THIOCARBAMOYLTHIO)ACETYL]PHENOTHIAZINE DERIVATIVES

被引：0

作者：

PALASKA, E ^{[1
]}

SARAC, S ^{[1
]}

SAFAK, C ^{[1
]}

ERDOGAN, H ^{[1
]}

EROL, K ^{[1
]}

ALPAN, RS ^{[1
]}

机构：

[1] ANADOLU UNIV,FAC MED,DEPT PHARMACOL,ESKISEHIR,TURKEY

来源：

ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH | 1992年 / 42-2卷 / 12期

关键词：

ANTICHOLINERGIC DRUGS; DITHIOCARBAMATES; PHARMACOLOGY; SYNTHESIS; SPASMOLYTICS;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Nineteen 10-[2-(NN-disubstituted thiocarbamolythio) acetyl]phenothiazine derivatives have been synthesized by the reaction of 10-chloroacetylphenothiazine with potassium salt of N,N-disubstituted dithiocarbamic acid derivatives. The structures of the compounds have been elucidated by UV, IR, H-1-NMR spectra and microanalysis. The anticholinergic activity of the compounds was determined by assessing the inhibition of acetylcholine using atropine sulfate as a control. Results are discussed in relation to the activity and structure of the synthesized compounds.

引用

页码：1453 / 1455

页数：3

共 50 条

[41] Preparation and characterisation of several new N-disubstituted 2-aminoselenophene derivatives
Zug, I
Hartmann, H
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES, 2002, 57 (04): : 420 - 426
[42] THE CUPROUS SALTS OF SOME N,N-DISUBSTITUTED DITHIOCARBAMIC ACIDS AND THEIR DEGREE OF POLYMERISATION
AKERSTROM, S
ACTA CHEMICA SCANDINAVICA, 1956, 10 (04): : 699 - 701
[43] AMINO ACIDS .I. SYNTHESIS OF SOME N,N-DISUBSTITUTED ALANINES
REMIZOV, AL
JOURNAL OF GENERAL CHEMISTRY USSR, 1964, 34 (10): : 3233 - &
[44] REACTIONS OF N,N-DISUBSTITUTED THIOBENZAMIDE BROMINE ADDUCTS WITH SOME OXYGEN NUCLEOPHILES
CORSARO, A
COMPAGNINI, A
PERRINI, G
JOURNAL OF CHEMICAL RESEARCH-S, 1984, (12): : 404 - 405
[45] AMINO ALCOHOL DERIVATIVES OF CYCLOBUTANE .3. N,N-DISUBSTITUTED AMINOMETHYL-2-HYDROXYMETHYLCYCLOBUTANES
SCHENONE, P
BIGNARDI, G
MOSTI, L
FARMACO-EDIZIONE SCIENTIFICA, 1972, 27 (03): : 200 - &
[46] LOCAL-ANESTHETICS .4. SYNTHESIS AND ACTIVITY OF 2-(N-SUBSTITUTED OR N,N-DISUBSTITUTED AMINOACETAMIDO)-4-SUBSTITUTED OR N,N-DISUBSTITUTED AMINOACETAMIDO-4,5-SUBSTITUTED THIAZOLES
LAKHAN, R
RAI, BJ
FARMACO-EDIZIONE SCIENTIFICA, 1986, 41 (10): : 788 - 793
[47] ANAESTHETIC PROPERTIES OF SOME NEW N-SUBSTITUTED AND N,N-DISUBSTITUTED DERIVATIVES OF 5,5-DIALLYL-BARBITURIC ACID
SANDBERG, F
ACTA PHYSIOLOGICA SCANDINAVICA, 1951, 24 (01): : 7 - 26
[48] On the coupling of aryldiazonium salts with N,N-disubstituted 2-aminothiophenes and some of their carbocyclic and heterocyclic analogues
Hartmann, Horst
Zug, Ines
Journal of the Chemical Society, Perkin Transactions 1, 2000, (24): : 4316 - 4320
[49] SOME N-MONO- AND N, N′-DISUBSTITUTED DERIVATIVES OF 2-PIPERAZINECARBONITRILE
Petride, Horia
Draghici, Constantin
Florea, Cristina
Maganu, Maria
REVUE ROUMAINE DE CHIMIE, 2008, 53 (07) : 515 - +
[50] ACYLATED DERIVATIVES OF SOME N,N'-DISUBSTITUTED AMIDINES
VIGIER, J
BOUCHERL.A
ANNALES PHARMACEUTIQUES FRANCAISES, 1971, 29 (12): : 638 - &

← 1 2 3 4 5 →