STUDIES ON SOME 10-[2-(N,N-DISUBSTITUTED THIOCARBAMOYLTHIO)ACETYL]PHENOTHIAZINE DERIVATIVES

被引：0

作者：

PALASKA, E ^{[1
]}

SARAC, S ^{[1
]}

SAFAK, C ^{[1
]}

ERDOGAN, H ^{[1
]}

EROL, K ^{[1
]}

ALPAN, RS ^{[1
]}

机构：

[1] ANADOLU UNIV,FAC MED,DEPT PHARMACOL,ESKISEHIR,TURKEY

来源：

ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH | 1992年 / 42-2卷 / 12期

关键词：

ANTICHOLINERGIC DRUGS; DITHIOCARBAMATES; PHARMACOLOGY; SYNTHESIS; SPASMOLYTICS;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Nineteen 10-[2-(NN-disubstituted thiocarbamolythio) acetyl]phenothiazine derivatives have been synthesized by the reaction of 10-chloroacetylphenothiazine with potassium salt of N,N-disubstituted dithiocarbamic acid derivatives. The structures of the compounds have been elucidated by UV, IR, H-1-NMR spectra and microanalysis. The anticholinergic activity of the compounds was determined by assessing the inhibition of acetylcholine using atropine sulfate as a control. Results are discussed in relation to the activity and structure of the synthesized compounds.

引用

页码：1453 / 1455

页数：3

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