CA2+-INDUCED CA2+ RELEASE IN INSULIN-SECRETING CELLS

被引：80
|
作者：
ISLAM, MS
RORSMAN, P
BERGGREN, PO
机构：
[1] KAROLINSKA INST, KAROLINSKA HOSP,DEPT ENDOCRINOL, ROLF LUFT CTR DIABET RES,BOX 60500, S-10401 STOCKHOLM 60, SWEDEN
[2] GOTHENBURG UNIV, DEPT MED PHYS, S-40033 GOTHENBURG, SWEDEN
来源：
FEBS LETTERS | 1992年 / 296卷 / 03期
关键词：
CA2+-INDUCED CA2+ RELEASE; SULFHYDRYL REAGENT; THIMEROSAL; INTRACELLULAR CA2+ TRANSPORT; INSULIN-SECRETING CELL; PERMEABILIZED CELL;
D O I：
10.1016/0014-5793(92)80306-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The sulphydryl reagent thimerosal (50-mu-M) released Ca2+ from a non-mitochondrial intracellular Ca2+ pool in a dose-dependent manner in permeabilized insulin-secreting RINm5F cells. This release was reversed after addition of the reducing agent dithiothreitol. Ca2+ was released from an Ins(1,4,5)P3-insensitive pool, since release was observed even after depletion of the Ins(1,4,5)P3-sensitive pool by a supramaximal dose of Ins(2,4,5)P3 or thapsigargin. The Ins(1,4,5)P3-sensitive pool remained essentially unaltered by thimerosal. Thimerosal-induced Ca2+ release was potentiated by caffeine. These findings suggest the existence of Ca2+ -induced Ca2+ release also in insulin-secreting cells.
引用
收藏
页码：287 / 291
页数：5
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