REGULATORY FUNCTIONS OF PROTEIN-KINASE-C IN GLOMERULAR MESANGIAL CELLS

被引：19
|
作者：
PFEILSCHIFTER, J
机构：
[1] Research Department, Pharmaceuticals Division, Ciba-Geigy Ltd., Basel
来源：
KLINISCHE WOCHENSCHRIFT | 1990年 / 68卷 / 22期
关键词：
Mesangial cells; Phosphatidylcholine; Phosphoinositide; Phospholipase C; Phospholipase D; Prostaglandin; Protein kinase C;
D O I：
10.1007/BF01798064
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Protein kinase C is a family of isozymes that are activated by hormone-stimulated phosphoinositide hydrolysis and participate in the signalling process by phosphorylating certain target proteins. In glomerular mesangial cells protein kinase C fulfills two major functions: it contributes to hormone-induced prostaglandin formation, and it acts as a negative feedback regulator of the inositol lipid signalling cascade. Furthermore, protein kinase C activates a phosphatidylcholine-degrading phospholipase D activity with as-yet-unknown cellular function. © 1990 Springer-Verlag.
引用
收藏
页码：1134 / 1137
页数：4
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