INFLUENCE OF CAPTOPRIL ON URINARY-EXCRETION OF FUROSEMIDE IN HYPERTENSIVE SUBJECTS

Influence of captopril on urinary excretion of furosemide was examined in a placebo‐controlled, crossover design. Furosemide (20 mg) was injected intravenously in eight hypertensive subjects with pretreatment with captopril (25 mg) or matching placebo. Urine samples for furosemide and sodium were collected during the following intervals: −60 ∼ 0, 0 ∼ 60, 60 ∼ 120, and 120 ∼ 180 minutes after furosemide. Blood samples for plasma renin activity (PRA) and angiotensin II (AII) were obtained, and blood pressure was measured at −60, 0, 60, 120, and 180 minutes after furosemide. No significant difference was observed in urinary excretion of furosemide, volume or sodium between these trials. Although PRA increased following furosemide with captopril, as predicted plasma AII did not increase. Blood pressure significantly decreased following the combined therapy, but not furosemide alone. These data indicate that the urinary excretion of furosemide and its subsequent diuretic effects are not influenced by captopril. 1990 American College of Clinical Pharmacology