Locotomor Activity, Learning and Memory in WAG/Rij Rats with Absence Epilepsy

被引：0
|
作者：
Karson, Ayse [1 ]
Onat, Filiz [2 ]
Balci, Fuat [3 ,4 ]
Ates, Nurbay [1 ]
机构：
[1] Kocaeli Univ, Fizyol Anabilim Dali, Kocaeli, Turkey
[2] Marmara Univ, Tip Fak, Farmakol Anabilim Dal, Istanbul, Turkey
[3] Rutgers State Univ, Dept Psychol, New Brunswick, NJ 08901 USA
[4] Rutgers State Univ, Rutgers Ctr Cognit Sci, New Brunswick, NJ 08901 USA
来源：
EPILEPSI | 2008年 / 14卷 / 03期
关键词：
Abscncc epilepsy; VVAG/Rij; rat; behavior; open field; passive avoidance; water maze; memory; locomotion;
D O I：
暂无
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Objectives: The aim of this study was to evaluate the behavioral characteristics of WAG/Rij rats, a genetic model for absence epilepsy. Materials and methods: The performance of WAG/Rij rats in passive avoidance, Morris-water maze and open-field tests were compared with the Wistar rats (control group). Results: Passive avoidance and rota-rod performance did not differ between the two groups. WAG/Rij rats exhibited longer escape latencies on the first day of training in Morris water-maze, however, this difference disappeared with further training and during the probe day (without the platform). WAG/Rij rats exhibited increased locomotor activity in the open-field test. Discussion: Results are discussed with respect to known behavioral and cognitive deficits that characterize patients with absence epilepsy.
引用
收藏
页码：167 / 175
页数：9
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