The aim of the present study was to compare the effect of Bricanyl Turbuhaler (0.5 mg x 1 terbutaline) with the effect of albuterol metered dose inhaler (0.1 mg X 2 albuterol) in patients with reproducible bronchoconstriction. The study was performed as a double-blind placebo-controlled trial in sixteen asthmatic adults. Bronchoconstriction was induced by steady state running on a treadmill. Both 0.5 mg terbutaline and 0.2 mg albuterol have good bronchodilating effects in patients with exercise-induced asthma. There was, however, a faster onset of action after albuterol. The clinical value of this observed difference is uncertain.
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Univ Hull, Castle Hill Hosp, Med Acad, Cottingham HU16 5JQ, East Yorkshire, EnglandUniv Hull, Castle Hill Hosp, Med Acad, Cottingham HU16 5JQ, East Yorkshire, England
Morice, Alyn H.
Hochmuth, Ludek
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FD Roosevelt Hosp, Banska Bystrica 97517, SlovakiaUniv Hull, Castle Hill Hosp, Med Acad, Cottingham HU16 5JQ, East Yorkshire, England
Hochmuth, Ludek
Ekelund, Jan
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AstraZeneca R&D, S-22187 Lund, SwedenUniv Hull, Castle Hill Hosp, Med Acad, Cottingham HU16 5JQ, East Yorkshire, England
Ekelund, Jan
Thoren, Anders
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AstraZeneca R&D, S-22187 Lund, SwedenUniv Hull, Castle Hill Hosp, Med Acad, Cottingham HU16 5JQ, East Yorkshire, England
Thoren, Anders
Puterman, Allan S.
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Kingsbury Hosp, Syringa House, Cape Town, South AfricaUniv Hull, Castle Hill Hosp, Med Acad, Cottingham HU16 5JQ, East Yorkshire, England