FOLATE AND COBALAMIN METABOLISM IN PLASMODIUM-FALCIPARUM

被引：12
|
作者：
KRUNGKRAI, J
WEBSTER, HK
YUTHAVONG, Y
机构：
[1] USA COMPONENT, ARMED FORCES RES INST MED SCI, DEPT IMMUNOL & BIOCHEM, BANGKOK 10400, THAILAND
[2] MAHIDOL UNIV, FAC SCI, DEPT BIOCHEM, BANGKOK 10400, THAILAND
来源：
PARASITOLOGY TODAY | 1990年 / 6卷 / 12期
关键词：
D O I：
10.1016/0169-4758(90)90148-W
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
During the past several years, Jerapan Krungkrai, H. Kyle Webster and Yongyuth Yuthavong have characterized the metabolic pathway of folate biosynthesis and folate-dependent reactions, including the cobalamin-dependent activity of methionine synthase, in P. falciparum grown in vitro. In this review, they discuss the implications of this work for understanding the mechanism of pyrimethamine resistance and the importance of cloning the dihydrofolate reductase gene. In addition, the role of cobalamin in P. falciparum will be considered. Interference with cobalamin use may represent a new target for combating the parasite. © 1990.
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页码：388 / 391
页数：4
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