A case of multiple synchronous lung adenocarcinomas with differing EGFR mutations

被引：0

作者：

Hasegawa, Hideomi ^{[1
]}

Kimura, Hideki ^{[2
]}

Shingyoji, Masato ^{[2
]}

Itami, Makiko ^{[2
]}

Araki, Akinobu ^{[2
]}

Yokoi, Sana ^{[2
]}

Kageyama, Hajime ^{[2
]}

Iizasa, Toshihiko ^{[2
]}

机构：

[1] Chiba Cardiovasc Ctr, 575 Tsurumai, Ichihara, Chiba 2900512, Japan

[2] Chiba Canc Ctr, Chuuou Ku, Chiba, Chiba 2600801, Japan

来源：

INTERNATIONAL CANCER CONFERENCE JOURNAL | 2013年 / 2卷 / 04期

关键词：

Lung cancer; Epidermal growth factor receptor (EGFR); Surgery; Adenocarcinoma;

D O I：

10.1007/s13691-013-0096-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We report a case of four synchronous lung cancers, each with a different epidermal growth factor receptor (EGFR) mutation in the tyrosine kinase domain. Bilateral double lung cancer was diagnosed clinically, and a left upper lobectomy and partial left S6 resection were performed. Right S1 segmental resection was performed later. Pathological examination revealed three lung adenocarcinomas in the left lung (S1 + 2, S3, and S6) and one in the right. Three different mutations of EGFR were identified with the polymerase chain reaction and direct sequencing of DNA from the three left lung tumors. The EGFR mutation on the right also differed from that of the left lung tumors.

引用

页码：224 / 228

页数：5

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