PROTEIN SECONDARY STRUCTURE DETERMINATION BY NMR - APPLICATION WITH RECOMBINANT HUMAN CYCLOPHILIN

被引：65
|
作者：
WUTHRICH, K [1 ]
SPITZFADEN, C [1 ]
MEMMERT, K [1 ]
WIDMER, H [1 ]
WIDER, G [1 ]
机构：
[1] SANDOZ PHARMA AG, PRAKLIN FORSCH, CH-4002 BASEL, SWITZERLAND
来源：
FEBS LETTERS | 1991年 / 285卷 / 02期
关键词：
PROTEIN STRUCTURE; SECONDARY STRUCTURE; NUCLEAR MAGNETIC RESONANCE; NMR STRUCTURE; CYCLOPHILIN;
D O I：
10.1016/0014-5793(91)80808-G
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
It is a unique trait of the NMR method for protein structure determination that a description of the polypeptide secondary structure can be obtained at an early stage and quite independently of the complete structure calculation. In this paper the procedures used for secondary structure determination are reviewed and placed in perspective relative to the other steps in a complete three-dimensional structure determination. As an illustration the identification of the regular secondary structure elements in human cyclophilin is described.
引用
收藏
页码：237 / 247
页数：11
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