SIMILARITY OF COPPER AND TECHNETIUM BINDING-SITES IN HUMAN-IGG

被引：10

作者：

ZAMORA, PO ^{[1
]}

MERCERSMITH, JA ^{[1
]}

MAREK, MJ ^{[1
]}

SCHULTE, LD ^{[1
]}

RHODES, BA ^{[1
]}

机构：

[1] LOS ALAMOS NATL LAB,MED RADIOISOTOPES RES PROGRAM,LOS ALAMOS,NM 87545

来源：

NUCLEAR MEDICINE AND BIOLOGY | 1992年 / 19卷 / 07期

关键词：

D O I：

10.1016/0883-2897(92)90142-L

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Kits for direct labeling of IgG with Tc-99m were used without modification for the preparation of [Cu-67]IgG. The IgG was pre-treated to generate thiolate groups which would bind Cu-67. The direct labeling of reduced IgG with Cu-67 was highly efficient, resulting in approx. 95% Cu-67 binding. Non-reduced IgG (negative control) had labeling efficiencies of less than 10%. IgG pre-exposed to Cu(II) had reduced amounts of Tc-99m bound to it. The results demonstrate a direct relationship between copper- and Tc-99m-binding sites in IgG.

引用

页码：797 / 802

页数：6

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