PHOSPHORUS-CONTAINING INHIBITORS OF HMG-COA REDUCTASE .3. SYNTHESIS OF HYDROXYPHOSPHINYL-ANALOGS OF THE MEVINIC ACIDS

被引：8

作者：

KARANEWSKY, DS ^{[1
]}

BADIA, MC ^{[1
]}

机构：

[1] BRISTOL MYERS SQUIBB PHARMACEUT RES INST,PRINCETON,NJ 08543

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 01期

关键词：

D O I：

10.1016/S0040-4039(00)60052-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of a series of hydroxyphosphinyl-containing analogues of the HMG-CoA reductase inhibitor trans-tetrahydrocompactin is described.

引用

页码：39 / 42

页数：4

共 50 条

[31] SYNTHESIS AND BIOLOGICAL-ACTIVITY OF ANNELATED PYRAZOLE-DERIVED HMG-COA REDUCTASE INHIBITORS
JAHNG, YD
KIM, JI
LEE, SI
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1994, 208 : 211 - MEDI
[32] DESIGN AND SYNTHESIS OF SECO-OXYSTEROL ANALOGS AS POTENTIAL INHIBITORS OF 3-HYDROXY-3-METHYLGLUTARYL-COENZYME-A (HMG-COA) REDUCTASE GENE-TRANSCRIPTION
LARSEN, SD
SPILMAN, CH
YAGI, Y
DINH, DM
HART, KL
HESS, GF
JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (15) : 2343 - 2351
[33] NEW HMG-COA REDUCTASE INHIBITORS - SYNTHESIS OF THE PURE ENANTIOMER OF SDZ 63-162
WATTANASIN, S
KATHAWALA, FG
PATEL, R
KAPA, P
CHEN, KM
SCALLEN, T
ENGSTROM, RG
WEINSTEIN, DB
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1988, 196 : 107 - MEDI
[34] Synthesis and biological activity of 4,5-polymethylenepyrazole-derived HMG-COA reductase inhibitors
Jin-Il Kim
Young Hee Choi
Yurngdong Jahng
Archives of Pharmacal Research, 1997, 20 : 158 - 170
[35] Synthesis and biological activity of 4,5-polymethylenepyrazole-derived HMG-CoA reductase inhibitors
Kim, JI
Choi, YH
Jahng, Y
ARCHIVES OF PHARMACAL RESEARCH, 1997, 20 (02) : 158 - 170
[36] HEPATIC AND NONHEPATIC STEROL SYNTHESIS AND TISSUE DISTRIBUTION FOLLOWING ADMINISTRATION OF A LIVER SELECTIVE HMG-COA REDUCTASE INHIBITOR, CI-981 - COMPARISON WITH SELECTED HMG-COA REDUCTASE INHIBITORS
BOCAN, TMA
FERGUSON, E
MCNALLY, W
UHLENDORF, PD
MUELLER, SB
DEHART, P
SLISKOVIC, DR
ROTH, BD
KRAUSE, BR
NEWTON, RS
BIOCHIMICA ET BIOPHYSICA ACTA, 1992, 1123 (02) : 133 - 144
[37] Hepatoselectivity of statins: Design and synthesis of 4-sulfamoyl pyrroles as HMG-CoA reductase inhibitors
Park, William K. C.
Kennedy, Robert M.
Larsen, Scott D.
Miller, Steve
Roth, Bruce D.
Song, Yuntao
Steinbaugh, Bruce A.
Sun, Kevin
Tait, Bradley D.
Kowala, Mark C.
Trivedi, Bharat K.
Auerbach, Bruce
Askew, Valerie
Dillon, Lisa
Hanselman, Jeffrey C.
Lin, Zhiwu
Lu, Gina H.
Robertson, Andrew
Sekerke, Catherine
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 18 (03) : 1151 - 1156
[38] Effect of HMG-CoA reductase inhibitors on proliferation and protein synthesis by rat hepatic stellate cells
Rombouts, K
Kisanga, E
Hellemans, K
Wielant, A
Schuppan, D
Geerts, A
JOURNAL OF HEPATOLOGY, 2003, 38 (05) : 564 - 572
[39] Synthesis of heterocyclic ring-fused analogs of HMG499 as novel degraders of HMG-CoA reductase that lower cholesterol
Li, Xing-Zi
Jiang, Shi-You
Li, Guo-Qiang
Jiang, Qian-Ru
Li, Jue-Wan
Li, Chen-Chen
Han, Yu-Qin
Song, Bao-Liang
Ma, Xin-Ran
Qi, Wei
Qiu, Wen-Wei
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 236
[40] Phosphorus-containing aminocarboxylic acids: XII. Synthesis of unsaturated analogs
Rozhko, LF
Ragulin, VV
RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 1999, 69 (07) : 1088 - 1092

← 1 2 3 4 5 →