PREPARATION OF NOVEL HETEROCYCLIC AMINO-ACIDS FROM N-(ARYLMETHYLENE)DEHYDROALANINE METHYL-ESTERS

被引：22

作者：

WULFF, G

KLINKEN, HT

机构：

[1] Institute of Organic Chemistry and Macromolecular Chemistry, Heinrich-Heine University Düsseldorf, 4000 Düsseldorf 1

来源：

TETRAHEDRON | 1992年 / 48卷 / 29期

关键词：

ALPHA; ALPHA'-DIAMINODICARBOXYLIC ACIDS; 3-AMINO-PIPERIDINE-3,6-DICARBOXYLIC ACIDS; 2,6-DIAZABICYCLO[3.2.1]OCTANE-1,5-DICARBOXYLIC ACIDS; NONPROTEINOGENIC AMINO ACIDS;

D O I：

10.1016/S0040-4020(01)89847-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-(Arylmethylene)dehydroalanine methyl esters undergo a stereoregulated dimerization reaction to produce heterocyclic alpha,alpha'-diaminodicarboxylic acid derivatives. Further transformation yields stable hydrochlorides of free alpha,alpha'-diaminodicarboxylic acids which represent either substituted 3-amino-piperidine-3,6-dicarboxylic acids or substituted 2,6-diazabicyclo[3.2.1]octane-1,5-dicarboxylic acids. These compounds represent new types of cyclic and bicyclic amino acids.

引用

页码：5985 / 5990

页数：6

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