PREPARATION OF NOVEL HETEROCYCLIC AMINO-ACIDS FROM N-(ARYLMETHYLENE)DEHYDROALANINE METHYL-ESTERS

被引：22
|
作者：
WULFF, G
KLINKEN, HT
机构：
[1] Institute of Organic Chemistry and Macromolecular Chemistry, Heinrich-Heine University Düsseldorf, 4000 Düsseldorf 1
来源：
TETRAHEDRON | 1992年 / 48卷 / 29期
关键词：
ALPHA; ALPHA'-DIAMINODICARBOXYLIC ACIDS; 3-AMINO-PIPERIDINE-3,6-DICARBOXYLIC ACIDS; 2,6-DIAZABICYCLO[3.2.1]OCTANE-1,5-DICARBOXYLIC ACIDS; NONPROTEINOGENIC AMINO ACIDS;
D O I：
10.1016/S0040-4020(01)89847-1
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
N-(Arylmethylene)dehydroalanine methyl esters undergo a stereoregulated dimerization reaction to produce heterocyclic alpha,alpha'-diaminodicarboxylic acid derivatives. Further transformation yields stable hydrochlorides of free alpha,alpha'-diaminodicarboxylic acids which represent either substituted 3-amino-piperidine-3,6-dicarboxylic acids or substituted 2,6-diazabicyclo[3.2.1]octane-1,5-dicarboxylic acids. These compounds represent new types of cyclic and bicyclic amino acids.
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页码：5985 / 5990
页数：6
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