EFFECTS OF PANAXADIOL SAPONINS ISOLATED FROM PANAXNOTOGINSENG ON INTRACELLULAR AND EXTRACELLULAR CALCIUM

被引：0

作者：

DAN, HX ^{[1
]}

ZHANG, BH ^{[1
]}

XIE, SR ^{[1
]}

YAO, JA ^{[1
]}

JIA, JN ^{[1
]}

机构：

[1] HUBEI MED COLL, XIANNING BRANCH, DEPT PHARMACOL, XIANNING 437100, PEOPLES R CHINA

来源：

ACTA PHARMACOLOGICA SINICA | 1993年 / 14卷

关键词：

PANAXADIOL; GINSENG; SAPONINS; PERHEXILINE; HEART ATRIUM; COLON; THORACIC AORTA; CALCIUM;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Panaxadiol saponins (PDS ) contain saponins Panax notoginseng B1 and E. The spontaneous beating induced by isoproterenol in isolated rat right atria and the increase of contractile force induced by Ca2+ in isolated guinea pig colon were inhibited by PDS 75 and 150 mug . ml-1, respectively and perhexiline 6.25 and 12.5 mumol . L-1, respectively. It suggested that PDS could block the potential-dependent and receptor-operated calcium channel in smooth muscle. PDS 150 mug . ml-1 and perhexiline 6.25 mumol . L-1 depressed the contractile force induced by norepinephrine and Ca2+ in isolated rat aortic strips in Ca2+-free Krebs' solution. It suggested that PDS and perhexiline not only inhibited the release of intracellular Ca2+ but also blocked the inflow of extracellular Ca2+.

引用

页码：S22 / S25

页数：4

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