EFFECTS OF PANAXADIOL SAPONINS ISOLATED FROM PANAXNOTOGINSENG ON INTRACELLULAR AND EXTRACELLULAR CALCIUM

被引：0
|
作者：
DAN, HX [1 ]
ZHANG, BH [1 ]
XIE, SR [1 ]
YAO, JA [1 ]
JIA, JN [1 ]
机构：
[1] HUBEI MED COLL, XIANNING BRANCH, DEPT PHARMACOL, XIANNING 437100, PEOPLES R CHINA
来源：
ACTA PHARMACOLOGICA SINICA | 1993年 / 14卷
关键词：
PANAXADIOL; GINSENG; SAPONINS; PERHEXILINE; HEART ATRIUM; COLON; THORACIC AORTA; CALCIUM;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Panaxadiol saponins (PDS ) contain saponins Panax notoginseng B1 and E. The spontaneous beating induced by isoproterenol in isolated rat right atria and the increase of contractile force induced by Ca2+ in isolated guinea pig colon were inhibited by PDS 75 and 150 mug . ml-1, respectively and perhexiline 6.25 and 12.5 mumol . L-1, respectively. It suggested that PDS could block the potential-dependent and receptor-operated calcium channel in smooth muscle. PDS 150 mug . ml-1 and perhexiline 6.25 mumol . L-1 depressed the contractile force induced by norepinephrine and Ca2+ in isolated rat aortic strips in Ca2+-free Krebs' solution. It suggested that PDS and perhexiline not only inhibited the release of intracellular Ca2+ but also blocked the inflow of extracellular Ca2+.
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页码：S22 / S25
页数：4
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