Potentiometric performances of polymer membrane electrode based on cyclosporin

The main component governing selectivity in ion-selective electrodes and optodes is the ionophore. For this reason, a member of natural products that possess selective ion-binding properties have long been sought after. By applying this principle, the performance of cyclosporin used as neutral carriers for calcium selective polymeric membrane electrode was investigated. The calcium ion-selective electrode based on cyclosporin gave a good Nernstian response of 26.6 mV per decade for calcium ion in the activity range 1x10(-6) M to 1x10(-2) M. The optimized calcium ion-selective electrode displayed very comparable selectivity for Ca2+ ion against alkali and alkaline earth metal ions, Na+, and Mg2+ in particular.