SYNTHESIS OF HIGH SPECIFIC ACTIVITY TRITIATED DIHYDROPYRIDINES - NICARDIPINE-H-3

被引：1
|
作者：
PARNES, H
HUANG, GT
机构：
[1] Institute of Organic Chemistry, Palo Alto, California, 94303
来源：
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1991年 / 29卷 / 01期
关键词：
DIHYDROPYRIDINES-H-3; NICARDIPINE-H-3; META-NITROBENZALDEHYDE-H-3; CALCIUM CHANNEL ENTRY BLOCKERS;
D O I：
10.1002/jlcr.2580290112
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The synthesis of high specific activity 3-nitrobenzaldehyde - ?? [4,6-H-3], a key intermediate in the general synthesis of tritiated 4-aryldihydropyridines, is described. This substance was then used to prepare the calcium channel entry blocker, nicardipine-[4',6'-H-3] at a specific activity of 51 Ci/mmole via the Hantzsch process.
引用
收藏
页码：87 / 93
页数：7
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