SYNTHESIS OF HIGH SPECIFIC ACTIVITY TRITIATED DIHYDROPYRIDINES - NICARDIPINE-H-3

被引：1
|
作者：
PARNES, H
HUANG, GT
机构：
[1] Institute of Organic Chemistry, Palo Alto, California, 94303
来源：
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1991年 / 29卷 / 01期
关键词：
DIHYDROPYRIDINES-H-3; NICARDIPINE-H-3; META-NITROBENZALDEHYDE-H-3; CALCIUM CHANNEL ENTRY BLOCKERS;
D O I：
10.1002/jlcr.2580290112
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The synthesis of high specific activity 3-nitrobenzaldehyde - ?? [4,6-H-3], a key intermediate in the general synthesis of tritiated 4-aryldihydropyridines, is described. This substance was then used to prepare the calcium channel entry blocker, nicardipine-[4',6'-H-3] at a specific activity of 51 Ci/mmole via the Hantzsch process.
引用
收藏
页码：87 / 93
页数：7
相关论文
共 50 条
  • [1] THE SYNTHESIS OF TRITIATED RIBOSYLZEATIN WITH HIGH SPECIFIC ACTIVITY
    LALOUE, M
    FOX, JE
    PHYTOCHEMISTRY, 1987, 26 (04) : 987 - 989
  • [2] SYNTHESIS OF TRITIATED THREONINE WITH A HIGH SPECIFIC ACTIVITY
    DELACOTTE, JM
    GALONS, H
    SCHOTT, D
    MORGAT, JL
    JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 1991, 29 (10): : 1141 - 1146
  • [3] THE SYNTHESIS OF TRITIATED METHOXAMINE WITH HIGH SPECIFIC ACTIVITY
    DEMARINIS, RM
    VILLANI, AJ
    BRUNGARD, D
    MEIER, J
    JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 1982, 19 (02): : 267 - 270
  • [4] Synthesis of tritiated antiviral isoxazoles at high specific activity
    J. A. Egan
    R. P. Nugent
    C. N. Filer
    Journal of Radioanalytical and Nuclear Chemistry, 2009, 279 : 935 - 936
  • [5] SYNTHESIS OF HIGH SPECIFIC-ACTIVITY TRITIATED PHENOXYBENZAMINE
    MENDELSO.W
    BLACKBUR.D
    SPAZIANO, V
    JOURNAL OF LABELLED COMPOUNDS, 1966, 2 (04): : 440 - &
  • [6] Synthesis of tritiated antiviral isoxazoles at high specific activity
    Egan, J. A.
    Nugent, R. P.
    Filer, C. N.
    JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, 2009, 279 (03) : 935 - 936
  • [7] Synthesis of physiologically active tritiated compounds using high specific activity tritiated water
    Myasoedov, NF
    Sidorov, GV
    Kramerov, VN
    Mishin, VI
    JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 1999, 42 (09): : 859 - 866
  • [8] GENERAL-SYNTHESIS OF HIGH SPECIFIC ACTIVITY TRITIATED PROSTANOIDS
    PARNES, H
    DEKECZER, S
    SHELTON, EJ
    APPLIED RADIATION AND ISOTOPES, 1988, 39 (06) : 540 - 540
  • [9] SYNTHESIS OF TRITIATED 1-NORADRENALINE OF HIGH SPECIFIC ACTIVITY
    HESSELBO, T
    LONG, RF
    JOURNAL OF LABELLED COMPOUNDS, 1966, 2 (04): : 440 - &
  • [10] SYNTHESIS OF TRITIATED ABSCISIC-ACID OF HIGH SPECIFIC ACTIVITY
    WALTON, D
    WELLNER, R
    HORGAN, R
    PHYTOCHEMISTRY, 1977, 16 (07) : 1059 - 1061
12345