SYNTHESIS OF DINUCLEOTIDES CONTAINING A BRIDGED NONCHIRAL INTERNUCLEOTIDE 5'-PHOSPHORAMIDATE OR 3'-PHOSPHORAMIDATE LINKAGE

被引：11

作者：

MAG, M ^{[1
]}

ENGELS, JW ^{[1
]}

机构：

[1] UNIV FRANKFURT,INST ORGAN CHEM,D-60439 FRANKFURT,GERMANY

来源：

TETRAHEDRON | 1994年 / 50卷 / 34期

关键词：

D O I：

10.1016/S0040-4020(01)81755-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of several dinucleoside phosphate derivatives which are linked by phosphoramidate bands [3'-O-P(=O)(O)-NH-5' or 3'-NH-P(=O)(O)-O-5'] has been accomplished. The internucleoside phosphoramidate linkage was performed using the Staudinger reaction which is directly followed by a Michaelis-Arbuzov type transformation. Due to the exclusive use of base labile blocking groups deprotection could be carried out very easily in a single step by treatment with concentrated ammonia for 24 hours at 55 degrees C.

引用

页码：10225 / 10234

页数：10

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