GROWTH STIMULATION OF SV3T3 CELLS BY TRANSFERRIN AND ITS DEPENDENCE ON BIOTIN

被引：32
|
作者：
YOUNG, DV
COX, FW
CHIPMAN, S
HARTMAN, SC
机构：
来源：
EXPERIMENTAL CELL RESEARCH | 1979年 / 118卷 / 02期
关键词：
D O I：
10.1016/0014-4827(79)90168-X
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A critical nutrient for the growth of SV3T3 (SV-40 transformed mouse embryo fibroblasts) cells is Fe. Fe must be added in the ferrous form or, if in the ferric state, with a suitable complexing agent. Both transferrin and Hb, as Fe complexes, will stimulate cell growth in biotin supplemented medium either with low serum (0.15% vol/vol) or serum-free. The growth stimulation by Fe (free or in complexed form) is dependent on the presence of biotin in the medium. The importance of transferrin as a serum growth factor was indicated.
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页码：410 / 414
页数：5
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