MULTIPLE AGE-ASSOCIATED MITOCHONDRIAL-DNA DELETIONS IN SKELETAL-MUSCLE OF MICE

被引：56

作者：

CHUNG, SS ^{[1
]}

WEINDRUCH, R ^{[1
]}

SCHWARZE, SR ^{[1
]}

MCKENZIE, DI ^{[1
]}

AIKEN, JM ^{[1
]}

机构：

[1] UNIV WISCONSIN,DEPT ANIM HLTH & BIOMED SCI,MADISON,WI 53706

来源：

AGING-CLINICAL AND EXPERIMENTAL RESEARCH | 1994年 / 6卷 / 03期

关键词：

AGING; MICE; MITOCHONDRIAL DNA DELETIONS;

D O I：

10.1007/BF03324239

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Multiple mitochondrial DNA (mtDNA) deletions have been associated with aging in humans and monkeys. Since the inbred mouse strain, C57BL/6, hers been extensively studied gerontologically, we sought to investigate its utility as a model for examining the importance of mtDNA deletions in aging. Using the polymerase chain reaction (PCR), vie analyzed hind limb skeletal muscle from mice of three age groups (5, 16 and 25 months) for the presence of age-associated mtDNA deletions. We observed multiple mtDNA deletions in all three age groups. Further, the number of deletions detected per mouse increased greatly tuith advancing age.

引用

页码：193 / 200

页数：8

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