EFFECTS OF CONVERSION OF PHENYLALANINE-31 TO LEUCINE ON THE FUNCTION OF HUMAN DIHYDROFOLATE-REDUCTASE

被引：23
|
作者：
PRENDERGAST, NJ
APPLEMAN, JR
DELCAMP, TJ
BLAKLEY, RL
FREISHEIM, JH
机构：
[1] MED COLL OHIO,DEPT BIOCHEM,CS 10008,TOLEDO,OH 43699
[2] ST JUDE CHILDRENS RES HOSP,DEPT BIOCHEM & CLIN PHARMACOL,MEMPHIS,TN 38101
[3] UNIV TENNESSEE,CTR HLTH SCI,COLL MED,DEPT PHARMACOL,MEMPHIS,TN 38163
来源：
BIOCHEMISTRY | 1989年 / 28卷 / 11期
关键词：
D O I：
10.1021/bi00437a020
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页码：4645 / 4650
页数：6
相关论文
共 50 条
  • [21] 2 RFLPS FOR THE HUMAN DIHYDROFOLATE-REDUCTASE GENE (DHFR)
    FEDER, JN
    BOWCOCK, A
    CAVALLISFORZA, LL
    SCHIMKE, RT
    NUCLEIC ACIDS RESEARCH, 1987, 15 (14) : 5906 - 5906
  • [22] PROPERTIES OF DIHYDROFOLATE-REDUCTASE FROM HUMAN-TUMORS
    BLAIR, JA
    PHEASANT, AE
    SALEH, AM
    SAHOTA, A
    WHITBURN, SB
    OATES, GD
    ALLAN, RN
    BRITISH JOURNAL OF CANCER, 1982, 46 (03) : 510 - 511
  • [23] REGULATION OF DIHYDROFOLATE-REDUCTASE IN HUMAN-BREAST CANCER-CELLS AND IN MUTANT HAMSTER-CELLS TRANSFECTED WITH A HUMAN DIHYDROFOLATE-REDUCTASE MINIGENE
    COWAN, KH
    GOLDSMITH, ME
    RICCIARDONE, MD
    LEVINE, R
    RUBALCABA, E
    JOLIVET, J
    MOLECULAR PHARMACOLOGY, 1986, 30 (01) : 69 - 76
  • [24] CHARACTERIZATION OF A PHE-31 TO LEU-31 (F-31-L) MUTANT OF HUMAN DIHYDROFOLATE-REDUCTASE (HDHFR)
    PRENDERGAST, NJ
    DELCAMP, TJ
    APPLEMAN, JA
    BLAKELEY, RL
    FREISHEIM, JH
    FASEB JOURNAL, 1988, 2 (05): : A1331 - A1331
  • [25] HUMAN DIHYDROFOLATE-REDUCTASE - REDUCTION OF ALTERNATIVE SUBSTRATES, PH EFFECTS, AND INHIBITION BY DEAZAFOLATES
    WILLIAMS, EA
    MORRISON, JF
    BIOCHEMISTRY, 1992, 31 (29) : 6801 - 6811
  • [26] METHOTREXATE RESISTANT HUMAN KB CELLS - SIZE HETEROGENEITY OF DIHYDROFOLATE-REDUCTASE RELATED RNAS AND EFFECT OF METHOTREXATE ON DIHYDROFOLATE-REDUCTASE ACTIVITY
    DOMIN, BA
    BASTOW, KF
    GRILL, SP
    CHENG, YC
    FEDERATION PROCEEDINGS, 1982, 41 (04) : 1052 - 1052
  • [27] EFFECT OF 11-OXAHOMOFOLATE AND ITS REDUCED DERIVATIVES ON HUMAN DIHYDROFOLATE-REDUCTASE AND ON HUMAN-CELLS HAVING DIFFERENT AMOUNTS OF DIHYDROFOLATE-REDUCTASE
    DOMIN, BA
    CHENG, YC
    NAIR, MG
    BIOCHEMICAL PHARMACOLOGY, 1982, 31 (02) : 255 - 256
  • [28] EFFECTS OF MALNUTRITION ON DIHYDROFOLATE-REDUCTASE LEVELS IN RAT TISSUES
    GROSSIE, VB
    HO, DHW
    BODEY, GP
    LOO, TL
    PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, 1978, 19 (MAR): : 207 - 207
  • [29] INSIGHTS INTO ENZYME FUNCTION FROM STUDIES ON MUTANTS OF DIHYDROFOLATE-REDUCTASE
    BENKOVIC, SJ
    FIERKE, CA
    NAYLOR, AM
    SCIENCE, 1988, 239 (4844) : 1105 - 1110
  • [30] A STRUCTURE-FUNCTION STUDY OF DIHYDROFOLATE-REDUCTASE BY PROTEIN ENGINEERING
    VILLAFRANCA, JE
    HOWELL, EE
    OATLEY, SJ
    WARREN, MS
    KRAUT, J
    PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES, 1986, 317 (1540): : 405 - 413
12345