CONTROL OF ACETYLCHOLINESTERASE GENE-EXPRESSION DURING MYOGENESIS

被引:70
|
作者
FUENTES, ME
TAYLOR, P
机构
[1] Department of Pharmacology 0636 University of California, San Diego La Jolla
关键词
D O I
10.1016/0896-6273(93)90169-R
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Acetylcholinesterase (AChE) and the nicotinic acetylcholine receptor show enhanced expression upon differentiation of C2-C12 myoblasts into myotubes. Northern blots and RNAase protection show substantial increases in the mRNAs encoding both proteins. In contrast to transcriptional control of gene expression of acetylcholine receptor subunits during differentiation, Ache mRNA levels increase through stabilization of the transcript. The transcriptional rate remains unchanged during Ache mRNA accumulation, whereas transcription rate increase for the receptor subunits. Inhibition of protein synthesis produces a dramatic superinduction of Ache mRNA in undifferentiated cells without affecting transcription rates, suggesting the presence of labile proteins that uniquely destabilize the mRNA. Hence, Ache mRNA in myoblasts shows rapid turnover, and upon differentiation, its level is increased by slowing the rate of mRNA degradation.
引用
收藏
页码:679 / 687
页数:9
相关论文
共 50 条
  • [41] REGULATION OF THE TRANSCRIPTION OF THE ACETYLCHOLINESTERASE GENE DURING MYOGENESIS - STUDY OF THE MOUSE PROMOTER ELEMENTS
    MUTERO, A
    CAMP, S
    LI, Y
    TAYLOR, P
    FASEB JOURNAL, 1993, 7 (07): : A1226 - A1226
  • [42] GLYCOLYTIC-ENZYMES GENE-EXPRESSION IN MYOGENESIS - PURIFICATION OF ENZYMES AND IMMUNOLOGICAL PROBES
    REISS, NA
    SCHWARTZ, RJ
    FEDERATION PROCEEDINGS, 1983, 42 (07) : 2214 - 2214
  • [43] DIHYDROPYRIDINE RECEPTOR GENE-EXPRESSION IS REGULATED BY INHIBITORS OF MYOGENESIS AND IS RELATIVELY INSENSITIVE TO DENERVATION
    SHIH, HT
    WATHEN, MS
    MARSHALL, HB
    CAFFREY, JM
    SCHNEIDER, MD
    JOURNAL OF CLINICAL INVESTIGATION, 1990, 85 (03): : 781 - 789
  • [44] CONTROL OF SPATIAL PATTERNS OF GENE-EXPRESSION DURING GASTRULATION IN THE ZEBRAFISH EMBRYO
    HOLDER, N
    FASEB JOURNAL, 1993, 7 (07): : A1056 - A1056
  • [45] THE CONTROL OF ASYMMETRIC GENE-EXPRESSION DURING CAULOBACTER CELL-DIFFERENTIATION
    MARCZYNSKI, GT
    SHAPIRO, L
    ARCHIVES OF MICROBIOLOGY, 1995, 163 (05) : 313 - 321
  • [46] TRANSCRIPTIONAL CONTROL OF GENE-EXPRESSION DURING DEVELOPMENT OF DICTYOSTELIUM-DISCOIDEUM
    LANDFEAR, SM
    LEFEBVRE, P
    CHUNG, S
    LODISH, HF
    MOLECULAR AND CELLULAR BIOLOGY, 1982, 2 (11) : 1417 - 1426
  • [47] CONTROL OF TUBULIN GENE-EXPRESSION DURING METACYCLOGENESIS OF TRYPANOSOMA-CRUZI
    RONDINELLI, E
    DEMOURANETO, RS
    SILVA, R
    SOARES, CMD
    CARVALHO, JF
    DECASTRO, FT
    FEBS LETTERS, 1986, 208 (02): : 379 - 385
  • [48] Influence of intronic sequences in the acetylcholinesterase gene on pre-mRNA splicing during myogenesis
    Luo, ZD
    Camp, S
    Mutero, A
    Taylor, P
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1998, 358 (01) : R156 - R156
  • [49] POST-TRANSCRIPTIONAL CONTROL OF GENE-EXPRESSION DURING FROG DEVELOPMENT
    SHEPHERD, GW
    FLICKINGER, RA
    JOURNAL OF CELL BIOLOGY, 1978, 79 (02): : A19 - A19
  • [50] BOUNDARY FUNCTIONS IN THE CONTROL OF GENE-EXPRESSION
    EISSENBERG, JC
    ELGIN, SCR
    TRENDS IN GENETICS, 1991, 7 (10) : 335 - 340