GAMMA-AMINOBUTYRIC-ACID (GABA-B) RECEPTOR-MEDIATED INHIBITION OF TYROSINE-HYDROXYLASE ACTIVITY IN THE STRIATUM OF RAT

被引：18
|
作者：
ARIASMONTANO, JA [1 ]
MARTINEZFONG, D [1 ]
ACEVES, J [1 ]
机构：
[1] NATL POLYTECH INST,CTR INVEST & ESTUDIOS AVANZADOS,DEPT FISIOL BIOFIS & NEUROCIENCIAS,MEXICO CITY 14,DF,MEXICO
来源：
NEUROPHARMACOLOGY | 1991年 / 30卷 / 10期
关键词：
TYROSINE HYDROXYLASE; BACLOFEN; GABA-B RECEPTORS; NEOSTRIATUM; DOPAMINE SYNTHESIS; NIGROSTRIATAL PATHWAY;
D O I：
10.1016/0028-3908(91)90132-U
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The effects of GABA and GABA agonists on calcium and depolarization-dependent stimulation of tyrosine hydroxylase activity in striatal slices were studied. Gamma-Aminobutyric acid and (-)baclofen inhibited, while muscimol and (+)baclofen did not affect, the stimulation of tyrosine hydroxylase. The inhibitory effect of GABA and (-)baclofen was blocked by the GABA(B) antagonist, phaclofen but not by the GABA(A) antagonist, picrotoxin. The data suggest that the activity of tyrosine hydroxylase on dopaminergic nigrostriatal terminals may be modulated by GABA via GABA(B) receptors.
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页码：1047 / 1051
页数：5
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